MINT: A Multipoint Injection Technology for Intraparenchymal Gene Transfer

Project Information

Problem

Efficient transduction of the entire putamen with AAV through a single procedure has been challenging. Doses of AAV required to achieve full putaminal transduction are much higher than initially thought.

Solution

The MINT systems are compatible with magnetic resonance imaging and standard surgical procedures. By increasing the number of injection sites, MINT reduces the duration of the injection procedure while improving the delivery and gene transfer efficiency.

Technology Type

Diagnostic

Aids with identifying the nature and cause(s) of a clinical problem or illness

Facilitator

Increases the efficacy of a clinical process or procedure

Therapeutic

Enables healing from or treatment of an illness or clinical problem

Monitor

Records/shares data as on-going surveillance of a clinical problem, process or procedure

PI/Inventor(s)

Pedro Gonzalez-Algere, MD

Associate Professor, Department of Neurology, Associate Professor and Director for Clinical Programs (CHOP)

Flavia Vitale, PhD

Assistant Professor of Neurology and Physical Medical & Rehabilitation

Cohort

2017-2018