Disease Modifying Hydrogels to Treat Knee Osteoarthritis

Project Information

Problem

Current treatment options for knee osteoarthritis do little to stop the deterioration of tissues in the joint and total knee arthroplasty surgeries are inevitable.

Solution

This project develops injectable hydrogels that locally target tissue degrading enzymes to preserve cartilage, bone, and synovial tissues.

Technology Type

Diagnostic

Aids with identifying the nature and cause(s) of a clinical problem or illness

Facilitator

Increases the efficacy of a clinical process or procedure

Therapeutic

Enables healing from or treatment of an illness or clinical problem

Monitor

Records/shares data as on-going surveillance of a clinical problem, process or procedure

PI/Inventor(s)

Brendan Purcell, PhD

CEO of Prohibix LLC

Jason Burdick, PhD

Robert D. Bent Professor of Bioengineering

Penn Engineering

Rob Mauck, PhD

Mary Black Ralston Professor for Education and Research in Orthopaedic Surgery and Professor of Bioengineering

Milt Zgonis, MD

Assistant Professor of Orthopedic Surgery

Co-Director, Human Tissue Laboratory

Penn Medicine

Company Formed

Prohibix

Cohort

2018-2019